All issues > Volume 36(8); 1993

Original Article

J Korean Pediatr Soc. 1993;36(8):1067-1072. Published online August 15, 1993.

Intermittent Central Nervous System Irradiation and Intrathecal Chemotherapy for Recurrent Central Nervous System Leukemia in Children

Joon Ho JH Bang¹, Nak Gyun NG Chung¹, Woo Gun WG Choi¹, Hack Ki HK Kim¹, Kyong Su KS Lee¹, Man Kyu MK Yang¹

¹Department of Pediatrics, Catholic University Medical College, Seoul, Korea

Abstract

Between 1986 and 1990, four children with recurrent CNS leukemia who had previous NS prophylaxis therapy were treated with intermittent central nervous system irradiation and intrathecal chemotherapy (IIC). There was no isolated CNS recurrence. One patient died from bone marrow relapse. Three patients are alive without evidence of disease for 33/12 year to 36/12 years after the diagnosis of recurrence of CNS leukemia. This experience suggests that IIIC may be an effective treatment for preventing the recurrence of CNS leukemia without any serious side effects.

Keywords :Acute lymphocytic leukemia, CNS irradiation, Intrathecal chemotherapy