All issues > Volume 36(9); 1993

Original Article

J Korean Pediatr Soc. 1993;36(9):1219-1226. Published online September 15, 1993.

Postnatal Changes of Cretine Kinase and Isoenzyme Activities in Normal and Asphyxiated Newborns

Ki Young KY Koo¹, Nam Geun NG Heo¹, Heng Mi HM Kim¹

¹Department of Pediatrics, College of Medicine, Kyung-Pook National University, Taegu, Korea

Abstract

This study was conducted to evaluate the postnatal changes of serum creatine kinase (CK)and its isoenzymes in normal and asphyxiated newborns. In normal newborns total CK, CK-MM and CK-MB reached a plateau between 2 and 24 hr after birth whereas the serum CK-BB remained stable after birth. CK-MM, CK-MB and CK-BB respectivily composed 90~94%, 5~7% and 1~5% of total CK during study period. In asphyxiated newborns total CK, CK-MM and CK-MB reached maximal value at 12hr after birth whereas CK-BB decreased after birth. There were no significant differences between normal and asphyxiate newborns in total CK, CK-MM and CK-MB during study period (up to 24 hrs after birth). But CK-BB of asphyiated newborn was elevated significantly(p<0.05)within 6 hrs after birth compared to normal newborns. There were no significant differences of CK and its isoenzymes between patients evaluated by 5min Apgar scores(0~3, 4~6 and 7~10) or degree of HIE (HIE stage 0~Ⅰ, Ⅱand Ⅲ). According to these results, the serum CK-BB is elevated in asphyxiated newborns during 1st 6hrs after birth but has no predictive values of the extent of cerebral damage.

Keywords :Asphyxia, Creatine kinase