All issues > Volume 36(10); 1993

Original Article

J Korean Pediatr Soc. 1993;36(10):1651-1358. Published online October 15, 1993.

Dermatophagoides Farinae Specific IgG-Subclass Antibody in Allergic Children

Young Mi YM Hong¹, Kyung Hyo KH Kim¹, Eun Ae EA Park¹, Gyoung Hee GH Kim¹

¹Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea

Abstract

For determining the distribution of specific IgE and IgG-subclass antibodies and their role in allergic disorders, we measured the serum levels of specific IgG-subclass and IgE antibodies to Dermatophagoides farinae(Df) on 60 atopic children, aged between 8 to 12. All of them had positive skin test to Df, and was grouped into three: children with asthma only (group 1), with rhinitis (group 2), and with them together (group 3). Every data were compared with that of 47 nomal children. ELISA (for IgG and IgG-subclass) and RIA(for IgE) were used. The results are as following. 1) Specific IgE-antibody is significantly higher in all three allergic groups, compared with normal control group. But there was no significant difference between three allergy groups. 2) Specific IgG, IgG1, IgG2, IgG4-antibodies were higher than those in normal control group, but IgG3 was not significant. IgG1 and IgG2 were elevated particularly in patients with asthma and rhintis, but IgG4 was elevated in asthma group. 3) The linear correlation between specific IgE and IgG1-antibody was significant (r=0.286), but IgG4 did not have this correlation with IgE. In conclusion, the levels of specific IgE is essential for the diagnosis of allergies, and IgG1and IgG4 seem to participate in allergic reactions with a different mechanism.

Keywords :Df, Specific IgG subclass