All issues > Volume 36(10); 1993

Original Article

J Korean Pediatr Soc. 1993;36(10):1434-1440. Published online October 15, 1993.

Plasma Immunoreactive Endothlin-1, Creatine Kinase and CK Isoenzyme and Its Relation to Neonate with-Asphyxia

Kang Woo KW Lee¹, Kee Hyoung KH Lee¹, Chang Sung CS Son¹, Young Chang YC Tockgo¹

¹Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea

Abstract

Endotheline-1(ET-1) is a potent vasoconstrictor peptide with 21 amino acid residues. ET-1 is thought to have a key role in vasoconstriction, and cardiac, renal, and endocrine actions of the peptide. Creatine Kinase(CK), also referred to as ATP-creatine-N-phosphotransferase, consists of either the B or M type. CK is found almost exclusively in muscle (MM), myocardium (MB), and brain (BB). It is to be an almost specific index of injury of myocardium and brain in hypoxic damage. I measured the ET-1, CK isoenzyme in neonates among asphyxia group (14 cases), as a control devide into two group, 1st group(birth weight≤2500g, n=9) and 2nd group(body weight>2500g, n=11). 1) There was no significant difference between asphyxia and control 1st, 2nd group during postnatal 24 hrs include cord blood on irET-1(p>0.05). 2) There was significant difference between asphyxia and control 1st, 2nd group during postnatal 24 hrs include cord blood on CK and CK isoenzyme(p<0.001). 3) There was significant difference between asphyxia and control 1st, 2nd group on CK-MB and CK-BB proportion(p<0.001). 4) There was significant difference between cord blood and postnatal 24 hrs on total CK level (p<0.001).

Keywords :Asphyxia, irET-1, CK and CK isoenzyme