All issues > Volume 36(10); 1993

Case Report

J Korean Pediatr Soc. 1993;36(10):1458-1465. Published online October 15, 1993.

Two Cases of Virus Associated Hemophagocytic Syndrome

Jae Hee JH Han¹, Hyun Chul HC Lee¹, Hwang Min HM Kim¹, Jong Soo JS Kim¹, Kyung Won KW Lee²

¹Department of Pediatrics, Wonju College of Medicine, Yonsei University, Wonju, Korea, Department of Radiology
²Department of Clinical Pathology, Wonju College of Medicine, Yonsei University, Wonju, Korea, Department of Radiology

Abstract

Virus associated hemophagocytic syndrome, class II histiocytoses, characterized by high fever, severe constitutional symptoms, abnormal liver function and coagulation, peripheral blood pancytopenia and histiocytic hyperplasis with prominent hemophagocytosis in bone marrow and lymph nodes has been reported and associated with active viral infection. It is non-malignant and reversible. It must be differentiated from histiocytic medullary reticuosis because of the inappropriateness of immunosuppressive or cytotoxic therapy which is the therapeutic method for HMR, but is contraindicated in the treatment of VAHS. This paper describes two patients whose clinicopathology was compatible with the diagnosis of virus associated hemophagocytic syndrome.

Keywords :Virus associated hemophagocytic syndrome