All issues > Volume 36(11); 1993

Case Report

J Korean Pediatr Soc. 1993;36(11):1630-1634. Published online November 15, 1993.

A Case of Carbamazepine-Induced Toxic Epidermal Necrolysis

Gi Chan GC Na¹, Kyung Seok KS Kim¹, Eun Gyeoung EG Jung¹, Kyyng Rae KR Moon¹, Sang Kee SK Park¹, Yeoung Bong YB Park¹

¹Department of Pediatrics, Collefge of Medicine, Chosun University, Kwang Jum Korea

Abstract

Drug-induced toxic epidermal necrolysis (TEN) is a bullous erythematous disease that is characterized by the appearance of scaled lesions and large sheets of pilling on the skin. A case of TEN occured in a 10 month old female patient. The characteristic skin lesions of TEN developed after oral administration of carbamazepine for a partial seizure. Thig case consists of prodrome of malaise, fever, anorexia, and conjunctivity followed by erythema & flaccid bullae formation. Diagnosis was confirmed by histologic findings. This patient was treated with a massive systemic corticosteroid, antibiotics, fluid and electrolytes, and topical measures. Authors experienced an extermely rare case of TEN due to carbamazepine, So report it with a brief review of literature.

Keywords :Carbamazepine, Toxic Epidermal Necrolysis