All issues > Volume 37(1); 1994

Original Article

J Korean Pediatr Soc. 1994;37(1):19-25. Published online January 15, 1994.

Prediction of Neurologic Outcome of Perinatal Asphyxia by Use of CK-BB Isoenzyme Measurements

Eun Sik ES Kang¹, Jung Hea JH Park¹, Hea Jin HJ Choeh¹, Chong Sung CS Chung¹, Kyuchul Kc Choeh¹

¹Department of Pediatrics, Eulji General Hospital, Taejon, Korea

Abstract

Creatine kinase (CK) isoenzyme are considered as a specific tissue injury marker. Brain tyupe isoenzyme of CK (CK-BB) was measured in 44 healthy and 33 asphyxiated preterm and fullterm infants. Samples were drawn from peripheral blood at six to ten hours after birth. There were no difference of CK-BB and CK-BB% between preterm and fullterm infants. CK-BB and CK-BB% were well correlated to the degree of hypoxic ischemic encephalopathy. Seventeen infants died in newborn period had higher CK-BB activity than 60 infants who survived at discharge. We conculuded that early CK-BB determination can be used as and indicator of neonatal brain damage and neonatal death. It is warranted to do long-term follow-up for evaluation of neurologic outcome.

Keywords :Creatiine Kinase (CK) isoenzyme, Birth asphyxia