All issues > Volume 37(1); 1994

Case Report

J Korean Pediatr Soc. 1994;37(1):115-112. Published online January 15, 1994.

A Case of Distal Renal Tubular Acidosis

Bin B Cho¹, Dong Sung DS Kim¹, Byung Churl BC Lee¹

¹Department of Pediatrics, Catholic University Medical College, Seoul, Korea

Abstract

Distal renal tubular acidosis (RTA) is a biochemical syndrome as a dificiency of hydrogen ion secretion by the distal tubule and collecting duct. Owing to the nature of the defect, hyperchloremic non-anion gap metabolic acidosis and high urine pH despite severe systemic acidosis is characterized. Typical manifestations of distal RTA are growth retardation, rickets, polyuria and nephrocalcinosis. We experienced a case of distal renal tubular acidosis in a 4 years old female child who comlained of growth retardation an gait disturbance. She showed typical hyperchloremic non-anion gap metabolic acidosis and persistent high urine pH. In radiographic examination. We found delayed bone age and severe rachitic changes of wrist, elbow, and knee as well as nephrocalcinosis. In ammonium chloride loading test, high urine pH persisted despite the lowering blood HCO3- concentration. After alkali therapy, she is in well condition with excellent growth velocity and absence of rachitic changes.

Keywords :Distal renal tubular acidosis, Hyperchloremic metabolic acidosis