All issues > Volume 37(2); 1994

Original Article

J Korean Pediatr Soc. 1994;37(2):231-239. Published online February 15, 1994.

Transmission of Hepatitis B Virus from Asymptomatic Carrier Mothers to Their Offspring Using the Polymerase Chain Reaction Technique

Jin Sook JS Kim¹, Young Ran YR Yoon¹, Mi Kyung MK Kim¹, Hye Kyung HK Han¹, Mi Ryung MR Um¹, Kyung Hoon KH Choi¹, Mi Na MN Lee¹, In Keol IK Moon², In Kweon IK Han³

¹Department of Pediatrics , Cheil General Hospital, Seoul, Korea
²Laboratory of Endocrinology, Cheil General Hospital, Seoul, Korea
³Department of Internal Medicine, Cheil General Hospital, Seoul, Korea

Abstract

Total 8,341 pregnant women who visited Obstetric clinic Cheil General Hospital from January 1991 to July 1992 were screened for HBsAg. Sixty five women with positive HbsAg who delivered healthy babies during that period and their infants are included in the study. HBsAg, Anti-HBs, Anti-HBc, HBeAg and Anti-HBe were tested by radioimmunoassay and hepatitis B virus DNA were studied by polymerase chain reaction technique in both mother's and babies serum. The results were as follow: 1) among 8,341 pregnant women who were screened for HBsAg 374 were asymptomatic carriers(4.5%). 2) The newborn babies born to 65 mothers who were positive HBsAg showed HBsAg in 4.6%, HBeAg 75.0%, anti-HBc 98.4% and hepatitis B virus DNA in 26.2%. 3) It showed discordance of HBeAg/anti-HBe, with hepatitis B virus DNA in newborn infants. 4) Follow up study at 8~20 months showed HBeAg and hepatitis B virus DNA in 2 infants out of 20.

Keywords :Hepatitis B virus, Polymerase chain reaction, Carrier