All issues > Volume 37(2); 1994

Original Article

J Korean Pediatr Soc. 1994;37(2):250-256. Published online February 15, 1994.

Acute Tubular Necrosis Associated with typhoid Fever

Pill-Jin PJ Shin¹, Ho-Sung HS Lee¹, Byoung-Soo BS Cho¹, Chang-Il CI Ahn¹, Mun-Ho MH Yang²

¹Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea
²Department of Anatomical Pathology, College of Medicine, Kyung Hee University, Seoul, Korea

Abstract

Acute tubular necrosis has been rarely reported as a complication of typhoid fever in the literature. We experienced four cases of acute tubular necrosis associated with typhoid fever in children. Patients showed significant titer of widal reaction associated with acute renal failure and one of them rised in 2 months after onset of clinical symptoms. Renal biopsy findings were compatible with acute tubular necrosis and immune complexes were not deposited in the glomeruli. Clinical and urinary findings were normalized by hemodialysis and antibiotic therapies. In conclusion, close longterm follow up of widal titer is mandatory in acute tubular necrosis, especially when associated with high fever.

Keywords :Typhoid fever, Acute tubular necrosis, Renal biopsy