All issues > Volume 37(3); 1994

Original Article

J Korean Pediatr Soc. 1994;37(3):383-389. Published online March 15, 1994.

Clinical analysis of Serum and Urine N-Acetyl-β-D-Glucosaminidase (NAG) in Renal Disease

Yo Han YH Chung¹, In Seok IS Lim¹, Chul Ha CH Kim¹, Byoung Hoon BH Yoo¹, Tae Sub TS Shim¹

¹Department of Pediatrics, College of Medicine, Chung-Ang University, Seoul, Korea

Abstract

Recently, NAG activity has gained increasing importance as an aid in the diagnosis of renoparenchymal diseases. Elevation of urine NAG activity has been found to be an indicator of renoparenchymal diseases. To evaluate the diagnostic value of the NAG activity test in the renal disease, we carried out clinical study on 31 cases of renal disease patients who had been admitted to the Department of Pediatrics, Chung-Ang University Hospital between March 1992 and February 1993. We analysed by two data: (1) Stastical Package for the Social Science (2) Students'T test. The results were as follows 1) The urine NAG activity significantly increased (p<0.05) to 69.95¡¾165.69 U/hr/mg Creatinine (U/hr/mg Cr) in the renal disease group compared to 3.66¡¾1.91 U/hr/mg Cr in the control group. 2) The serum NAG activity was 11.69¡¾5.18 U/L in the renal disease group and 10.58¡¾4.04 U/L in the control group. There was no significant difference in the serum NAG activity between two groups. 3) In the renal disease group, the serum NAG activity was 10.78¡¾3.32 U/L in male and 12.53¡¾6.47 U/L in female. There was no significant difference between both sexes. In the renal disease, the urine NAG activity was 33.62¡¾30.67 U/hr/mg Cr in male and 114.05¡¾241.62 U/hr/mg Cr in female. There was no significant difference between both sexes (p<0.05). 4) In the renal disease group, the urine NAG activity increased 314.73¡¾420.39U/hr/mg Cr in the 2 years old group but there was no significant difference of urine NAG activity compared to above 2 years old group. 5) The urine NAG activities were 93.10¡¾193.04 U/hr/mg Cr in the poteinuria subgroup and 13.34¡¾7.62 U/hr/mg Cr in the nonproteinuria subgroup and 3.66¡¾1.91 U/hr/mg Cr in the control group. There was no significant difference between the proteinuria subgroup and the nonproteinuria subgroup. but there was significant difference between nonproteinuri subgroup and control grouop (p<0.005).

Keywords :N-Acetyl-β-D-Glucosaminidase (NAG), Renal disease