All issues > Volume 37(3); 1994

Original Article

J Korean Pediatr Soc. 1994;37(3):397-404. Published online March 15, 1994.

Tc-99m HMPAO Brain SPECT in a Patient with Neonatal Seizure and Right Cerebral Hemiatrophy

Hye Young HY Kang¹, Kook In KI Park¹, Ran R Namgung¹, Chul C Lee¹, Chang Jun CJ Coe¹, Dong Gwan DG Han¹, Tae Sub TS Chung², Woo Hee WH Jung³

¹Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
²Department of Diagnostic Radiology, College of Medicine, Yonsei University, Seoul, Korea
³Department of Pathology, College of Medicine, Yonsei University, Seoul, Korea

Abstract

Functional brain imaging is very important in the diagnosis and evaluation of the various neurologic disorders. In addition to electroencephalography (EEG) and positron emission tomography (PET), single photon emission computed tomography (SPECT) have increasingly gained importance in determination of disturbances in regional brain functions. Both ictal and interictal Tc-99m hexamethyl-propyleneamine oxime single photon emission computed tomography (Tc-99m HMPAO SPECT) was done in a patient with the neonatal seizure and right cerebral hemiatrophy. The left parieto-occipital area revealed increased radioactivity during ictal stage and decreased radioactivities during interictal stage on Tc-99m HMPAO Brain SPECT. This brain area was thought to be a epileptogenic focus. Ictal and interictal Tc-99m HMPAO brain SPECT could be a safe and sensitive diagnostic method in localization of epileptogenic foci.

Keywords :Functional brain imaging, Tc-99m HMPAO brain SPECT, Epileptogenic focus