All issues > Volume 37(3); 1994

Case Report

J Korean Pediatr Soc. 1994;37(3):422-429. Published online March 15, 1994.

A Case of Congenital Hypoprothrombinemia

Jong Kwang JK Lee¹, Hae Won HW Cheon¹, Jung Hwa JH Lee¹, Kwang Chul KC Lee¹, Soon Kyum SK Kim¹

¹Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea

Abstract

Congenital hypoprothrombinemia is a rare congenital coagulation defect. The clinical signs are manifestation of generalized bleeding tendency such as; mucosal bleeding, hypermenorrhea and post tooth extraction hemorrage. It is associated with prolongation of PT and PTT with normal thrombin time and decreased serum prothrombin level. A case with congenital hypoprothrombinemia was experienced by the authors. A 36 days old male baby was admitted with palor skin and vomiting started one day before admission. Right side brain parenchymal hemorrhage and left shift of lateral ventricle were on brain CT scan. Prolongation of prothrombin time and partial prothrombin time with decreased serum prothrombin level were resulted. Serum factor I, V, VII, VIII, IX and X were within normal level. We report a case congenital hypoprothrombinemia with a brief review of related literatures.

Keywords :Congenital hypoprothrombinemia