All issues > Volume 37(6); 1994

Original Article

J Korean Pediatr Soc. 1994;37(6):842-849. Published online June 15, 1994.

A Clinical Observation on Lupus Nephritis in Children

Kang Mo KM Ahn¹, Jae Sung JS Ko¹, Hye Won HW Park¹, Il Soo IS Ha¹, Hae Il HI Cheong¹, Yong Y Choi¹, Hee Joo HJ Kim²

¹Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
²Department of Pediatrics, Boramae Hospital, Seoul, Korea

Abstract

We reviewed the clinical features, histrologic patterns and clinical courses of 30 children with lupus nephritis retrospectively, and the results were summerized as follows; 1) The male to female ratio was 1:2.8, and the mean age at the onset was 108/12 years. 2) The clinical symptoms were diverse, and malaise, weight loss, anorexia, fever and malar rash were the most frequent findings. 3) Among the immunologic tests, FANA and anti-ds-DNA test revealed the highest sensitivity with positive rates of 97% and 87%, respectively. 4) Clinically, 57% of patients had active nephrotic syndrome at the onset, and 33% showed asymptomatic urinary abnormalities. Histologically, diffuse proliferative lupus nephritis (Class IV) was the most common findings (70%) 5) During the follow-up period, one children with Class IV lupus nephritis expired. And 8 out of 9 cases with renal insufficiency at the onset showed improvement of renal function after treatment with corticosteroid and cytotoxic agents. In conclusion, the clinical features and histologic findings of lupus nephritis in children were diverse. Early diagnosis and proper treatment can prevent rapid deterioration of renal function and improve long-term survival rate.

Keywords :Lupus nephritis, Children