All issues > Volume 37(7); 1994

Case Report

J Korean Pediatr Soc. 1994;37(7):999-1005. Published online July 15, 1994.

A Case of Pulmonary Blastoma

Yun Jeong YJ Chang¹, Jeong Hee JH Kim¹, Sun Ki SK Kim¹, Byong Kwan BK Son¹, Joon Mi JM Kim², Young Chae YC Chu²

¹Department of Pediatrics, Inha University Medical College, Sung Nam, Korea
²Department of Anatomical Pathology, Inha University Medical College, Sung Nam, Korea

Abstract

Pulmonary blastoma is a rare type of malignant lung tumor comprised of epithelial and mesenchymal elements reminiscent of fetal lung. Mesenchymal element may show various patterns of differentiation toward mature tissue, such as cartilage, smooth muscle, and bone. Rhabdomyoblastic differentiation in pulmonary blastoma is quite rare. Our case of pulmonary blastoma with rhabdomyoblastic differentiation documented by electron microscopy and immunohistochemistry. Usually it has been treated with surgery, but both chemotherapy and radiotherapy have been used against the metastatic disease, and as the adjuvant setting. A 28/12-year-old girl is described who was presented with pulmonary blastoma. She underwent surgical excision of the tumor, followed by the T2protocol, a 8 cycles of combination chemotherapy consisting of actinomycin-D, adriamycin, vincristine and cyclophosphamide with the radiation therapy to the left chest cage(180 cGy¡¿11times). The patient has been off therapy without any evidence of relapse for 24 months. We report a case of pulmonary blastoma with brief review of related literatures.

Keywords :Pulmonary blastoma, Rhabdomyoblastic differentiation, Surgical excision, Combination chemotherapy, Radiation therapy