All issues > Volume 37(9); 1994

Original Article

J Korean Pediatr Soc. 1994;37(9):1245-1250. Published online September 15, 1994.

The Roles of IgG and Albumin as a Predictor of Frequent Relapse

Jae-Ho JH Lee¹, Jong-Gyun JG Kim¹

¹Department of Pediatrics, College of Medicine, Chungnam National University, Taejeon, Korea

Abstract

The etiology of nephrotic syndrome is unknown. The characterization were proteinuria, hypoalbuminemia, generalized edema and hyperlipidemia. To assess the recurrence factors in the nephrotic syncrome, we measured serum immunoglobulin(IgG, IgA, IgM), albumin, complement, cholesterol and the 24-hour total urine protein at the initial relapse of nephrotic syndrome. Each data of frequent and infrequent relapsed nephrotic syndrome were compared. In total 67 cases, 18 cases were frequent relapsers and 26 cases were infrequent relapsers and 23 cases were normal control without renal disease. The levels of IgG and albumin in frequent relapser were 304 mg/dl and 1.59g/dl as compared with 440mg/dl and 2.06g/dl in infrequent relapsers. The levels of IgG and albumin were significantly lower in frequent relapsers than infrequent relapsers(p<0.05). This study might be userful to predict that very low levels of IgG and albumin at the first relapse might be related to high risk chances of frequent relapse in children with nephrotic syncrome.

Keywords :Nephrotic Syndrome, Frequent Relapser, Infrequent Relapser, IgG, Albumin