All issues > Volume 37(9); 1994

Case Report

J Korean Pediatr Soc. 1994;37(9):1317-1324. Published online September 15, 1994.

A Case of Cerebral Infarcion due to Thrombosis Associated with Focal Segmental Glomerulosclerosis and Steroid Resistant Nephrotic Syndrome

Dae Woo DW Kim¹, Heon Lang HL Park¹, Sang Man SM Shin¹, Eun Mi EM Kim¹

¹Department of Pediatrics, School of Medicine, Soon Chun Hyang University, Seoul, Korea

Abstract

Focal segmental glomerulosclerosis is the renal histopathologic lesion observed in 10% of children with idopathic nephrotic syndrome. Complications include infection, thrombosis, hypocalcemia and adverse effect of steroid use. The incidnce of thrombosis reported ranges from 10~40%. The pathogenesis are changes in coagulation system, decrease of Antithrombin III, increase platelet aggregability and steroid or diuretics use. These changes take place passively as a result of increased protein synthesis and urinary loss of low molecular weight protein. We experienced a case of cerebral infarction due to thrombosis associated with focal segmental glomerulosclerosis and steroid resistant nephrotic syndrome in a 11 year old male patient who had been hospitalized because of convulsion and semicoma. MRI showed an evolving infarct in the occipital lobe, decreased antithrombin III and increased factor VIII on coagulation factor assay. We hereby report a case of cerebral infarction due to thrombosis associated with focal segmental glomerulosclerosis and steroid resistant nephrotic syndrome with a brief review of related literature.

Keywords :Focal segmental glomerulosclerosis, Steroid resistant nephrotic syndrome, Cerebral thrombosis