All issues > Volume 37(10); 1994

Original Article

J Korean Pediatr Soc. 1994;37(10):1357-1363. Published online October 15, 1994.

Risk Factors of Bronchopulmonary Dysplasia in Premature Infants Treated with Mechanical Ventilation and Restrictive Fluid Therapy

Min Soo MS Park¹, Kook In KI Park¹, Hye Jung HJ Choo¹, Moon Sung MS Park¹, Ran R Namgung¹, Chul C Lee¹, Dong Gwan DG Han¹

¹Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea

Abstract

In addition to many of the widely accepted risk factors of bronchopulmonary dysplasia(BPD), such as prematurity, oxygen toxicity, barotrauma, and infection, the amount of fluid intake during the early phase of life has recently been reported to be an important factor, especially the amount of colloid. Forty-one premature infants who were admitted to the NICU of Severance Hospital, Yonsei University College of Medicine between Jan. 1990 and Jun. 1992 and treated for respiratory difficulty with mechanical ventilation and restrictive fluid therapy were included in the study. Fourteen were diagnosed as BPD and the rest were grouped as Non-BPD. We confirmed prematurity, low birth weight, high oxygen concentration, high ventilator pressures and rates, perinatal asphyxia, acidosis, and low blood pressures as risk factors. However, with restrictive fluid therapy that we have used, there was no difference in the amount of total fluid, of crystalloid, or of colloid between BPD and Non-BPD groups, as were the urine output, serum electrolyte concentrations, and percent body weight change. The amount of colloid when used for the maintenance of adequated blood pressures and for the prevention and treatment of hypovolemia, oliguria, anemia of sepsis under the scheme of restrictive fluid therapy would not influence adversely in the development of BPD. Instead, the amount of colloid used may imply the severity of illness of the patient; that is, the more sevenre the condition of the patient the more the amount of colloid used.

Keywords :Bronchopulmonary dysplasia(BPD), Colloids