All issues > Volume 37(12); 1994

Original Article

J Korean Pediatr Soc. 1994;37(12):1717-1724. Published online December 15, 1994.

Comparison of Therapeutic Result of Oral Corticosteroid Versus Intravenous Gammaglobulin in Childhood Acute ITP

Jong-Hwan JH Kim¹, Hae-Won HW Kim¹, Hong-Ja HJ Kang¹, Woo-Sik WS Chung¹, Kil Seo KS Kim¹

¹Department of Pediatrics, Dae Dong Hospital, Busan, Korea

Abstract

A clinical study was conducted to compare effectiveness of IV Globulin with that of steriod in childhood acute ITP. We carried out an experiment to 36 patients of acute ITP who recovered over 50,000/mm3 of platelet count and not to recur in 6 months. Study group consist of 10 children who were treated with steriod only (Group A), 13 children who were treated with IV Globulin (0.4g/kg/d, 5 days, Group B), and 13 children combined with steroid(Group C). Study period was from January 1988 to December 1992, following results were obtained. 1) There were no significant difference in sex ratio, age distribution, pretreatment hemoglobin level, platelet count and prolonged bleeding time among study groups. 2) The days which platelet count reached to 50,000/mm3, 100,000/mm3, 150,000/mm3 were 3.7 days (Group A), 2.1 days(Group B), and 2.3 days(Group C), respectively(p<0.05). 3) Complete response rates within 4 weeks did not show significant difference (90% in Group A, 84. 6% in Group B, 92.3% in Group C), the complete response rate within 1 week were significantly different among three group (44.4% in Group A, 90.9% n Group B, 83.3% in Group C)(p<0.05). In conclusion, it is more desirable for early treatment of a childhood ITP because IV Globulin is easy to normalize platelet count in a short time.

Keywords :ITP, Intravenous gamma globulin, Steriod