All issues > Volume 38(6); 1995

Original Article

J Korean Pediatr Soc. 1995;38(6):835-842. Published online June 15, 1995.

Comparison Between 24-hour Integrated Growth Hormone Concentrations and Pharmacological Provocation Tests in Children with Short Statue

Mi Jung MJ Park¹, Duk Hi DH Kim¹, Ho Seong HS Kim²

¹Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
²Department of Pediatrics, Ewha Womans University College of Medicine, Seoul, Korea

Abstract

Purpose
: The ability to respond to pharmacologial provovation tests may not necessary reflect actuaol secretory patterns of growth hormone. Therefore, the aim of this study in to evaluate the 24-h IC-GH and compare this with their resposnses to standard pharmacological provocation tests for growth hormone comcentrations and to evaluate peak frequency and peak amplitude during 24-h IC-GH in children with short stature.
Methods
: We evaluated 22 cases. Pharmacological growth hormone provocation tests were done with L-dopa (0.5g/1.73㎡) and regular insulin (0.1I/kg). Fourteen were growth hormone deficiency, three were idiopathic short starue, five were normal vontrola. The 24-h IC-GH was sampled every 30minutes using the continuous blood witdrawal pump.
Results
: 1) Twenty-four hour IC-GH were significantly different among 3 groups. Normal contrel group had mean IC-GH value of 5.8±1.1ng/ml, growth hormone dificiency group had 0.8±0.7ng/ml, idiopathic short stature group had 3.6±0.4ng/ml. 2) Significant correlation was found between pharmacological peak GH concentrations and mean 24-h IC-GH. 3) In cases of idiopathic short stature, pharmacological peak GH, were normal, but 24-h peak frequencies and amplitudes were lower compared to normal control.
Conclusion
: In cases of patients with subnormal growth hormone concentrations on provocation tests, measuring 24-h IC-GH is not needed, but in case of normal or subnormal growth hormone concentrations on provocation tests and with subnormal yearly growth rates, it is recommended to measeue 24-h IC-GH.

Keywords :Comparison, 24h-ICGH, Pharmacological Provocation Tests, Short Statue.