All issues > Volume 38(7); 1995

Original Article

J Korean Pediatr Soc. 1995;38(7):963-969. Published online July 15, 1995.

Sex Hormone Binding Globulin Levels in Children with Insulin Dependent Diabetes Mellitus

Duk Hi DH Kim¹, Mi Jung MJ Park¹, Ho Sung HS Kim²

¹Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea
²Department of Pediatrics, Ehwa Womans University, College of Medicine, Seoul, Korea

Abstract

Purpose
: Sex hormone binding globulin(SHBG) is produced in liver and binds to testostero-ne and estradiol. Plasma SHBG levels are increased by estrogen and thyrotoxicosis and decreased by testostrone, insulin, growth hormone, prolactin, obesity and noninsulin dependent diabetes mellitus. SHBG levels in patients with NIDDM is known to be higher than normal, but SHBG levels in children with IDDM is controversial. The aims of our study are to examine SHBG levels in ID-DM children and to evaluate factors which affect SHBG levels.
Methods
: We measured SHBG levels in 40 IDDM children(mean age : 11.8¡¾44 yr) and 24 normal children(11.4¡¾4.1 yr).
Results
: The SHBG level was lower in puberty than prepurtal age in both IDDM and normal controls. However, no significant differences was found between IDDM and normal controls. In pubertal boys with IDDM, serum testostrone level was lower than normal.
Conclusion
: SHBG levels in children with IDDM was not significantly different from normal controls. To understand the relationship between SHBG level and it's regulatory mechanism further study will be needed.

Keywords :Sex hormone binding globulin, Insulin dependent diabetes mellitus, Insulin, Puberty