All issues > Volume 38(7); 1995

Original Article

J Korean Pediatr Soc. 1995;38(7):970-975. Published online July 15, 1995.

Study on Anti-neutrophil Cytoplasmic Antibodies in Children with Henoch-Schölein Purpura

Shin Jong SJ Lee¹, Woo Yeong WY Chung¹, Chul Ho CH Kim¹, Jeong Nyeo JN Lee²

¹Department of Pediatrics, Pusan Paik Hospital, College of Medicine, Inje University, Pusan, Korea
²Department of Clinical Parthology, Pusan Paik Hospital, College of Medicine, Inje University, Pusan, Korea

Abstract

The presence of IgG, IgA and IgM antineutrophil cytoplasmic antibodies(ANCA) were inves-tigated in 32 children with Henoch-Schölein Purpura(HS purpura), in 14 children with HS pur-pura nephritis who were confirrned by renal biopsy and in 12 control children using flow cytom-etry(FASCan, Beckton-Dickinson, Co, USA) and indirect immunofluorescence technique(Sigma Diagnostics, USA). There were no evidence of IgG, IgA or IgM cytoplasmic ANCA(p-ANCA), and perinuclear ANCA(c-ANCA) in the sera of 32 children. These results suggest that ANCA are not involved in the pathogenesis of vasculitis in HS purpura & HS purpura nephritis.

Keywords :Henoch-Schölein purpura, Anti-neutrphil cytoplasmic antibodies