All issues > Volume 38(9); 1995

Case Report

J Korean Pediatr Soc. 1995;38(9):1283-1287. Published online September 15, 1995.

A Case of Acyclovir Induced Acute Tubular Necrosis

Mi Ya MY Park², Mee Kyung MK Namgoong², Hwang Min HM Kim², Baek Keun BK Lim², Sun Hee SH Jung¹

¹Department of Pathology, Yonsei University, Wonju College of Medicine, Wonju, Korea
²Department of Pediatricsy, Yonsei University, Wonju College of Medicine, Wonju, Korea

Abstract

Acyclovir is generally regarded as a safe and highly effective antiviral agent in normal, as well as in immunocompromised hosts. Major renal complication was unusual. However, reversible renal dysfunction has been reported. The impairment of renal nephropathy resulting from crystal formation in the renal tubules or the collecting ducts. But we experienced a case of immunocompetent patient who developed severe and rapidly progressive acute renal failure due to tubular necrosis without crystal formation during the administration of acyclovir. So we report with a brief review and its related literatures.

Keywords :Acyclovir, Acute Tubular Necrosis, Crystal