All issues > Volume 38(9); 1995

Case Report

J Korean Pediatr Soc. 1995;38(9):1288-1292. Published online September 15, 1995.

A Case of Spontaneously Remitted Congenital Minimal Change Nephrotic Syndrome

Tae Sun TS Ha¹, Kyung Hee KH Lee¹, Beom Soo BS Park¹, Heon Seok HS Han¹

¹Department of Pediatrics, Chungbuk National University, College of Medicine, Cheongju, Korea

Abstract

Nephrotic syndrome is a condition with severe proteinuria, hypoalbuminemia, and edema. When the syndrome develops within the first 3 months of life, it is generally considered as congenital and the overall outcome in this group seems to be worse than in miniaml change lesion that occurs at an older age regardless of the pathologic findings. A female infant with congenital nephrotic syndrome was diagnosed as having minimal change lesion and treated with deflazacort as recommended protocol by ISKDC. But, there was no response to steroid, so the dosage of steroid was tapered. After 14 weeks from initiation of therapy, proteinuria disappeared and generalized edema became diminished. Therefore, we conclude that she recovered spontaneously and completely. This reinforces the view that reversible congenital minimal change nephrotic syndrome does occur and that is not a single disease with a universally dismal prognosis.

Keywords :Congenital nephrotic syndrome, Minimal change nephrotic syndrome, Spontaneous remission