All issues > Volume 38(12); 1995

Original Article

J Korean Pediatr Soc. 1995;38(12):1620-1628. Published online December 15, 1995.

Changes of Cerebral Blood Flow Velocity before and after Closure of Ductus Arteriosus using Doppler Ultrasound in Normal Full-term Newborns

Myung Su MS Lee¹, Young Mi YM Hong¹, Kyung Hee KH Kim¹

¹Department of Pediatrics, Ewha University, College of Medicine, Seoul, Korea

Abstract

Purpose
: With PDA, major fluctuations of blood flow are noted between opening and closure of ductus arteriosus and there is an increase in the amplitude of each pulse of blood flow. The purpose of this study was to evaluate the changes of cerebral blood flow before and after closure of ductus arteriosus in healthy term newborns.
Methods
: Forty-two normal term newborns (22: patent ductus arteriosus group, 20: closed ductus arteriosus group) were studied. Cerebral blood flow velocity and pulsatility index were estimated using color Doppler ultrasound in anterior cerebral artery during the first days of life.
Results
: 1) There was no significant difference in blood velocity and integral in ascending aorta, brachiocephalic artery, common carotid artery, subclavian artery, and pulmonary artery. 2) Heart rate and blood pressure were not significantly different in two groups. 3) Cerebral systolic velocity, integral, diastolic integral and AUVC was not significantly different. But diastolic velocity was lower and PI was higher in PDA group. 4) Cerebral systolic and diastolic velocities were increased with increasing postnatal age, and PI was decreased with increasing postnatal age. In the first day lower diastolic velocity and higher PI were shown in PDA group. After the 3rd day, there was no significant change in two groups. 5) In PDA group, Qp/Qs had no correlation with systolic velocity, integral and diastolic integral. But, Qp/Qs had correlation with diastolic velocity (r= -0.50), mean cerebral blood flow velocity (r=-0.59), and pulsatility index(r=0.63).
Conclusion
: In newborn with patent ductus arteriosus, decreased diastolic velocity can influence cerebral blood flow circulation. Therefore closed monitoring in fullterm neonates who have PDA with large shunt is necessary because of the possibility to develop intraventricular hemorrhage and necrotizing enterocolitis, if perinatal asphyxia is associated.

Keywords :Cerebral blood flow, Ductus arteriosus, Color Doppler ultrasound