All issues > Volume 39(5); 1996

Case Report

J Korean Pediatr Soc. 1996;39(5):732-737. Published online May 15, 1996.

A Case of Chronic Recurrent Multifocal Osteomyelitis

Weon Young WY Lee¹, Eell E Ryoo¹, Mi Jin MJ Jeong¹, Kye Hwan KH Seol¹, Kil Hyen KH Kim¹, Hak Su HS Lee¹

¹Department of Pediatrics, Chungang Gil Hospital, Inchon, Korea

Abstract

Chronic recurrent multifocal osteomyelitis(CRMO) is an unusual inflammatory process involving multiple osseous sites. No causative agent can be consistently isolated from these lesions despite multiple biopsies and the affected child purses a clinical course of chronic remissions and exacerbations independent of antibiotic therapy. Biopsy of the lesions did not reveal any pathogens. Immunologic investigation revealed no abnormality common to the patient and there was no indication of agenetic etiology. The natural history of chronic recurrent multifocal osteomyelitis appears to be slow, spontaneous resolution of the osseous lesions without specific treatment. We experienced a case of CRMO in an 11-year-old girl who had complained of fever, pain on knee and wrist joints for several weeks. We studied the clinical, radiographic, histological findings in this patient and we report a case of CRMO with brief review of related literature.

Keywords :Osteomyelitis, Multifocal lesions, Chronic recurrent disease