All issues > Volume 39(8); 1996

Case Report

J Korean Pediatr Soc. 1996;39(8):1162-1167. Published online August 15, 1996.

A Case of Combined Congenital Deficiency of Factor V and Factor VIII

Kue Chang KC Cho¹, Soo Kyung SK Lee¹, Il Kyung IK Kim¹, Ho H Sung¹, Chang Hee CH Choi¹

¹Department of Pediatrics, Seoul Adventist Hospital, Seoul, Korea

Abstract

Hemorrhagic disease of newborn by combined blood clotting factor deficiencies is very rare. Combined deficiency of factor V and factor VIII is the most common form among these cases, and inherited by autosomal recessive trait. Clinical findings are easy bruising, posttraumatic bleeding and bleeding after tooth extractions, and the main laboratory findings are prolonged partial thromboplastin time (PTT) and prothrombin time (PT) that are different from hemophilia A only with prolonged PTT. We experienced a case of combined congenital deficiency of factor V and factor VIII in a 1-day-old boy. We report the case with brief review of literature.

Keywords :Bleeding disorders, Factor V deficiency, Factor VIII deficiency, Hemorrhagic disease of newborn