All issues > Volume 40(3); 1997

Case Report

J Korean Pediatr Soc. 1997;40(3):393-407. Published online March 15, 1997.

Three Cases of Cardiac Arrythmias Associated with Intravenous Methylprednisolone Pulse Therapy

Jun Ho JH Lee¹, Jun J Huh¹, Myung Dong MD Shin¹, Dong Kyu DK Jin¹, Il Soo IS Ha¹, Hae Il HI Cheong¹, Chung Il CI Noh¹, Yong Y Choi¹

¹Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea

Abstract

Methylprednisolone(MP) is administered by means of intravenous pulse therapy especially in the patients with focal segmental glomerulosclerosis(FSGS). There have been reports of its complications in a few increasing frequency. We experienced three cases of cardiaccomplications during intravenous pulsetherapy.Therewere onecaseof2¡ÆA-V block(Mobitztype I) and two cases of bradycardia and hypotension. In the former,2¡ÆA-V block in the first case deveoloped 45 hours after MP infusion and subsided subsequently but reappeared athis EKG checked after 4 months. All of these complications resolved spontaneously. We should be awared of the fact that arrythmia resulting from MP infusion can be fetal.Therefore when IMPT are attempted, we should keep in mind of emergency life-saving preparations at bedside.

Keywords :Methylprednisolone, Arrhythmia