All issues > Volume 40(4); 1997

Case Report

J Korean Pediatr Soc. 1997;40(4):578-583. Published online April 15, 1997.

A Case of Congenital Acute Megakaryoblastic Leukemia with Down Syndrome

Nan Yee NY Kye², Kon Hee KH Lee², Jae Kook JK Cha², Hye Sun HS Yoon², Won Keun WK Song¹

¹Department of Clinical Pathology, Hallym University College of Medicine, Seoul, Korea
²Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea

Abstract

We experienced a case of congenital acute megakaryoblastic leukemia with Down syndrome. The patient was admitted due to characteristic facial figure of Down syndrome and abdominal distension. Acute megakaryoblastic leukemia was diagnosed with abundant megakaryoblast in peripheral blood smear, severe myelofibrosis in bone marrow biopsy and positive platelet glycoprotein Ⅲa receptor. On third hospital day, the patient expired due to DIC and pulmonary hemorrhage. Authors report the case with review of literature.

Keywords :Congenital acute megakaryoblastic leukemia, Down syndrome