All issues > Volume 40(6); 1997

Original Article

J Korean Pediatr Soc. 1997;40(6):794-800. Published online June 15, 1997.

The Expression of Fcγ Receptors in Cord and Adult Blood Granulocytes

Kyung Hyo KH Kim¹, Gyoung Hee GH Kim¹, Ju Young JY Seoh², Hae-Kyung HK Park²

¹Department of Pediatrics, College of Medicine, Ewha Woman`s University, Seoul, Korea
<sup>2</sup>Department of Microbiology, College of Medicine, Ewha Woman`s University, Seoul, Korea

Abstract

Purpose
: The immature neonatal immune system is thought to result in increased risk of infection. Receptors for the Fc moiety of IgG(FcγR) are important in antibody-mediated clearance of microbes by granulocytes and monocytes/macrophages. As an approach to understand their role in neonatal life, we compared the constitutive expression of the three Fc receptors-FcγRI(CD64), Fcγ RII(CD32) and FcγRIII(CD16)-of neonatal granulocytes with those of adult granulocytes.
Methods
: Using quantitative immunofluorescence by flow cytometry, we have compared the constitutive expression of the three Fc receptors-FcγRI(CD64), FcγRII(CD32) and FcγRIII(CD16)- by neonatal and adult blood granulocytes.
Results
: The proportion of FcγRI＋ granulocytes is significanly high in cord blood compared to that of adult. However, the proportions of FcγRII＋ or FcγRIII＋ cells are significanly low in cord blood compared to those of adlut.
Conclusion
: There were differences in the expression of FcγR on granulocytes between cord blood and adult peripheral blood. This results suggest that the differences in FcγR expression may be contributed to the differences in functional activity.

Keywords :Cord blood, Granulocytes, FcγR