All issues > Volume 40(7); 1997

Case Report

J Korean Pediatr Soc. 1997;40(7):1021-1025. Published online July 15, 1997.

A Case of Chronic Granulomatous Disease Which is Improved by Interferon-γ Therapy

Jae Choon JC Kim¹, Soon Seong SS Park¹, Myung Ja MJ Yun¹, Dong Hyuk DH Keum¹

¹Department of Pediatrics, Kangbuk Samsung Hospital, Seoul, Korea

Abstract

Chronic granulomatous disease is a group of rare disorders characterized by a disease of oxidative metabolism of phagocytes with deficit of antimicrobial activity. Also, it has clinical features of chronic pyogenic infection, granuloma formation, hypergammaglobulinemia, anemia and leukocytosis. We experienced a case of chronic granulomatous disease with chronic recurrent infection, hypergammaglobulinemia and liver abscess. It was confirmed by modified NBT test. The result of patient' s NBT test was less than 11%. The patient received subcutaneous injection of interferon-γ, 200 million unit(0.1mg/m2 of body surface area per dose), on three consecutive days per week for 3 weeks and her symptom was improved. Then, we report a case of chronic granulomatous disease which is improved by interferon-γ therapy with brief review of literature.

Keywords :Chronic granulomatous disease, Interferon-γ therapy