All issues > Volume 40(10); 1997

Original Article

J Korean Pediatr Soc. 1997;40(10):1453-1457. Published online October 15, 1997.

Treatment of Intravenous Immune-Globulin Resistant Kawasaki Disease with Corticosteroids

Dae-Eui DE Hong¹, Kyung-Yil KY Lee¹, Ji-Whan JW Han¹, Sung-Soo SS Hwang¹, Kyong-Su KS Lee¹

¹Department of Pediatrics, Catholic University Medical College, Seoul, Korea

Abstract

Purpose
: To evaluate the efficacy of steroid therapy on prevention of development and progression of coronary artery aneurysm in intravenous immune globulin(IVIG)-resistant Kawasaki disease, we treated three children with high dose of intravenous methylprednisolone followed by low dose oral prednisolone.
Methods
: We selected three children with Kawasaki disease who did not repond or who initially responded but soon developed recrudescent fever after retreatment of IVIG(total 4gm/kg). These three patients were treated with high dose methylprednisolone(10mg/kg) intravenously and followed by low dose prednisolone(1mg/kg) orally for 7 days. Echocardiographic evalutions were performed within 8 days of admission (before steroid therapy), at discharge and 1 month after discharge.
Results
: All three patients showed rapid normalization of clinical symptoms and did not developed significant coronry artery abnormalities. No adverse reaction was observed.
Conclusions
: Steroid therapy(mini pulse methylprednisolone and prednisolone therapy) is valuable for patients with Kawasaki disease resistant to intravenous immune globulin therapy.

Keywords :Kawasaki disease, Methylprednisolone therapy, Intravenous immune globulin