All issues > Volume 40(10); 1997

Case Report

J Korean Pediatr Soc. 1997;40(10):1470-1473. Published online October 15, 1997.

A Case of Reversible Biliary Pseudolithiasis After Ceftriaxone Therapy

Hye Kyung HK Lee¹, Young Chang YC Kim¹, Young Tong YT Kim²

¹Department of Pediatrics, Soonchunhyang University Medical college, Chunan, Korea
²Department of Diagnostic Radiology, Soonchunhyang University Medical college, Chunan, Korea

Abstract

Ceftriaxone, a potent third-generation semisynthetic cephalosporine, is widely used for treatment various bacterial infections in children. There have been some reports that transient appearance of gallbladder sludge was often demonstrated by abdominal sonography in patients treated with ceftriaxone. Reversible biliary pseudolithiasis was used to describe this phenomenon. We present a case of biliary pseudolithiasis which appeared to be related to intravenous ceftriaxone therapy in children who received ceftriaxone to treat meningitis. The recommended ceftriaxone dose was 100mg/kg/day and a total duration of administrations was 21 days. Abdominal sonographic examination showed nothing prior to antibiotic therapy, however, multiple tiny hyperechogenic materials were observed in gallbladder on day 7 of treatment. This patient did not demonstrate any symptoms. Follow-up abdominal sonography examination revealed that gallbladder materials began to resolve spontaneously on third day of posttherapy and complete resolution was observed on day 13 after cessation of ceftriaxone therapy.

Keywords :Reversible Biliary Pseudolithiasis, Ceftriaxone