All issues > Volume 41(5); 1998

Original Article

J Korean Pediatr Soc. 1998;41(5):593-598. Published online May 15, 1998.

A Clinical Study of Antithrombin Ⅲ Therapy for Disseminated Intravascular Coagulation in Neonates

Ji Young JY Kim¹, Cheong Nyen CN Kim¹, Myoung Jae MJ Chey¹, Cheol Young CY Cheong¹

¹Department of Pediatrics, Inje University, College of Medicine Sanggye Paik Hospital, Seoul, Korea

Correspondence Ji Young JY Kim ,Email: 1

Abstract

Purpose
: The purpose of this study is to evaluate the clinical effect of antithrombin Ⅲ concentrates in disseminated intravascular coagulation(DIC) of neonates.
Methods
: We reviewed the clinical records of 11 newborn patients who had been admitted and diagnosed as DIC at the neonatal intensive care unit of Sanggye Paik Hospital from November, 1995 to September, 1996.
Results
: There were 6 males and 5 females. In 9 cases(81.8%), gestational age was less than 37 weeks and birth weight was less than 2,500g. Sepsis was the most common underlying disease in 9 cases(81.8%), followed by respiratory distress syndrome, necrotizing enterocolitis, and fulminant hepatitis. The etiologic organisms of sepsis, were gram negative organisms, fungus, and gram positive organisms in decreasing order. There were signs of gastrointestinal tract hemorrhage, pulmonary hemorrhage, and intracranial hemorrhage as a result of DIC. In the clinical outcome of DIC patients, 6 out of 11 patients survived(54.5%).
Conclusion
: Administration of antithrombin Ⅲ concentrates in DIC of neonates produces improvement of clinical course and survival.

Keywords :Antithrombin Ⅲ, Disseminated intravascular coagulation