All issues > Volume 41(6); 1998

Original Article

J Korean Pediatr Soc. 1998;41(6):808-812. Published online June 15, 1998.

Antineutrophil Cytoplasmic Antibody in Kawasaki Disease

Soh-Yeon SY Kim¹, So Young SY Kim¹, Wonbae Wb Lee¹, Kyong Su KS Lee¹, Ji-Min JM Kang²

¹Department of P ediatrics, Catholic University Medical College, Seoul, Korea
²Department of Clinical Pathology, Catholic University Medical College, Seoul, Korea

Correspondence Wonbae Wb Lee ,Email: 1

Abstract

Purpose
: Antineutrophil cytoplasmic antibody(ANCA) has been identified in various disorders including Wegener' s granulomatosis, microscopic polyarteritis and Kawasaki disease. Measuring this antibody has a diagnostic role. It facilitates monitoring disease activity and may also help understand the pathogenesis of the diseases in which it is found. We investigated the correlation between the hematologic findings and ANCA in acute Kawasaki disease and the diagnostic potential of ANCA to predict coronary artery involvement.
Methods
: Thirty-eight patients who met the diagnostic criteria for Kawasaki disease were enrolled in this study. We sampled and investigated the hematologic findings and the assay of ANCA before intravenous immunoglobulin treatment and weekly echocardiographs weekly.
Results
: There was no sexual difference between ANCA positive and negative group. The age in ANCA positive group was significantly lower than in ANCA negative group. Duration of fever before treatment in ANCA positive group were not significantly different from those in ANCA negative group. In ANCA positive group, the mean WBC count and the mean ESRs were higher than in ANCA negative group. There was no relation between ANCA and coronary artery involvement
Conclusion
: The assays of ANCA in acute Kawasaki disease does not help to predict disease activity and coronary artery involvement.

Keywords :Kawasaki disease, Antineutrophil cytoplasmic antibody