All issues > Volume 42(11); 1999

Original Article

J Korean Pediatr Soc. 1999;42(11):1516-1523. Published online November 15, 1999.

Implication of vacA s1 Genotype of Helicobacter pylori in Children

Yae Jean YJ Kim¹, Hae Young HY Park², Mi Ae MA Lee³, Jeong Wan JW Seo¹

¹Department of Pediatrics, Ewha Womans University, College of Medicine, Seoul, Korea
²Department of Biochemistry, Ewha Womans University, College of Medicine, Seoul, Korea
³Department of Clinical Pathology, Ewha Womans University, College of Medicine, Seoul, Korea

Correspondence Jeong Wan JW Seo ,Email: 1

Abstract

Purpose
: Recently vacA s1 genotype of Helicobacter pylori was known to be associated with enhanced inflammation and peptic ulceration. To evaluate the association of the vacA s1 genotype with enhanced inflammation and peptic ulceration in children, we performed a polymerase chain reaction(PCR) for vacA s1 genotype.
Methods
: Twenty-seven CLO test-positive children were enrolled. They also revealed histological detection of bacteria and positive ureC gene by PCR in gastric biopsy specimens. The vacA s1, s2 and cagA genotypes were assayed by PCR in gastric biopsy specimens.
Results
: There were no association between vacA s1 genotype with peptic ulceration, severe inflammatory reaction, histological density of H. pylori, and formation of lymphoid follicle. None of our patients showed intestinal metaplasia. The vacA s1 genotype with or without cagA gene was not associated with peptic ulceration and enhanced inflammation.
Conclusion
: This study suggested that vacA s1 genotype of H. pylori was not associated with peptic ulceration and enhanced inflammation in Korean children.

Keywords :Helicobactoer pylori, vacA s1, cagA, Children