All issues > Volume 43(4); 2000

Original Article

J Korean Pediatr Soc. 2000;43(4):489-495. Published online April 15, 2000.

Antibody Response and Adverse Reaction Following Immunization with MMR Vaccine Produced on Human Diploid Cells in Korean Children

Sung Hee SH Oh¹, Jin Han JH Kang², Young Mo YM Sohn³, Hoan Jong HJ Lee⁴, Bok Yang BY Pyun⁵, Chang Hwi CH Kim⁵

¹Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea
²Department of Pediatrics, College of M edicine, The Catholic University of Korea, Seoul, Korea
³Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
⁴Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
⁵Department of Pediatrics, College of Medicine, Soonchunhyang University, Korea

Abstract

Purpose
: This prospective study was performed to evaluate the immunogenecity and safety of MMR vaccine(Triviraten Berna￠c) in Korea children.
Methods
: Seventy-three infants aged between 12 to 18 months were recruited from several university hospitals between December 1995 to June 1996. MMR vaccine(Triviraten Berna￠c) was administrered and blood was obtained before and 6-10 weeks after vaccination. IgG antibodies against measles, mumps and rubella viruses were measured by enzyme immunoassay. Untoward reactions were observed immediately after vaccination and for the following 4 weeks.
Results
: Seroconversion rate against measles virus following MMR vaccination was 100%(18/18, infants), and geometric mean titers(GMT)(95% confidence intervals(CI) before and after vaccination were 3.77(3.13-4.98) and 66.51(49.93-129.62), repectively. Seroconversion rate against mumps virus was 85.9%(55/64 infants), and GMT(95% CI) before and aftervaccination in 32 vaccinees were 3.37(3.05-3.95) and 76.11(71.30-126.70), respectively. Untoward reactions following MMR vaccination were not severe the pre- and post vaccination CBC results were also comparable.
Conclusion
: Antibody response and untoward reactions following MMR vaccination in Korean children appear comparable to previous reports. Further investigation is needed for the immunogenecity of MMR vaccine with a larger population and for the protective efficacy of the vaccine, especially against mumps.

Keywords :Measles, Mumps, Rubella, Vaccination, Immunogenecity, Adverse reaction, Safety