All issues > Volume 43(7); 2000

Case Report

J Korean Pediatr Soc. 2000;43(7):978-982. Published online July 15, 2000.

Two Cases of Thin Basement Membrane Nephropathy presented with Minimal Change Nephrotic Syndrome

Young Mee YM Seo¹, Jae Gul JG Chung², En Sil ES Yu², Jin Yeong JY Jeong³, Young Seo YS Park¹

¹Department of Pediatrics, Asan M edical Center
²Department of Diagnostic P athology, Asan M edical Center
³Department of Pediatrics, Ulsan University Hospital, College of Medicine, University of Ulsan

Abstract

Thin basement membrane nephropathy(TBMN) is defined histologically as follows : 1) By light microscopy only minor abnormalities are detected in the glomeruli at most minor mesangial widening. 2) By electron microscopy, diffuse thinning of glomerular basement membrane is demonstrated. 3) By immunofluorescence, absence of immunoglobulins and complement components is demonstrated. 4) Alport`s syndrome and systemic diseases that may affect the glomerular structure have been excluded. TBMN presented frequently with recurrent or persistent microscopic hematuria. Massive proteinuria such as in nephrotic syndrome rarely occurs in TBMN. We reported two cases of TBMN presented with typical minimal change nephrotic syndrome.

Keywords :Thin basement membrane nephropathy, Minimal change nephrotic syndrome