All issues > Volume 43(11); 2000

Original Article

J Korean Pediatr Soc. 2000;43(11):1430-1439. Published online November 15, 2000.

Effects of Partial Liquid Ventilation on Gas Exchange, Hemodynamics, and Pulmonary Function in Newborn Piglet with Respiratory Distress

Yun Sil YS Chang¹, Won Soon WS Park¹

¹Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Abstract

Purpose
: To evaluate gas exchange, hemodynamics and pulmonary function during partial liquid ventilation(PLV) using PFC(perfluorodecalin), compared with conventional gas ventilation in newborn piglets with saline lavage-induced respiratory distress.
Methods
: In a total of 16 instrumented and ventilated piglets, acute respiratory distress(below 70 mmHg of PaO2 at FiO2 1.0) was induced by repeated saline pulmonary lavage. The piglets were randomized to receive either gas ventilation only(control group, n=8) or PLV(PLV group, n=8) by 3 consecutive intratracheal instillations of 10mL/kg of perfluorodecalin at lavage baseline and at 30, 60min after lavage. All animals were mechanically ventilated for 150min after lavage with time-cycled pressure-limited gas ventilation, a peak inspiratory pressure of 30cm H2O, frequency of 30breaths/min, FiO2 1.0 and a positive end-expiratory pressure of 4cm H2O. All measurements were made at 30min interval afterwards to 150min after lavage.
Results
: All animals developed severe hypoxemia, hypercarbia, and acidosis due to increased transpulmonary shunt fraction after saline lavage, which persisted during the experiments in control group. PaO2 significantly increased with increases in dosage of PFC from 56¡¾6 to 235¡¾90 mmHg and PaCO2 also significantly decreased in the PLV group. Venous admixture and pH showed significant differences between the two groups. Pulmonary dynamic compliance, tidal volume and mean airway resistance were also significantly improved in the PLV group. However, hemodynamic parameters were similar in both groups.
Conclusion
: PLV with perfluorodecalin improves gas exchange and pulmonary function in newborn piglets with saline lavage-induced respiratory distress.

Keywords :Partial liquid ventilation, Perfluorodecaline, Respiratory distress, Gas exchange, Pulmonary function, Hemodynamics, Piglet