All issues > Volume 43(11); 2000

Original Article

J Korean Pediatr Soc. 2000;43(11):1480-1487. Published online November 15, 2000.

Serum Lipid Levels and Fatty Acid Metabolism in the Rat with Adriamycin Induced Cardiomyopathy

Young Mi YM Hong¹, Hye Ran HR Yoon²

¹Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea
²Seoul Medical Science Institude, Seoul, Korea

Abstract

Purpose
: Adriamycin induced cardiomyopathy is irreversible and may procede to clinical congestive heart failure. Recently, it has been suggested that adriamycin may exert cardiomyopathy due to inhibition of transport across mitochondrial membranes mediated by the carnitine palmitoyltransferase system(CPT I). The effect of adriamycin on fatty acid metabolism according to cumulative dose was not clarified. The purpose of this study was to ascertain the acute effect of adriamycin on lipid and fatty acid metabolism accoring to cumulative dose.
Methods
: Sprague-Dawley rats were divided into two groups. The first group was control. The second group was given intraperitoneal injection with adriamycin(5mg/kg) twice a week for 2 weeks. Serum lipid (total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol) and fatty acid levels were analyzed on the first day, 8th day, and 11th day after injection of adriamycin.
Results
: Total cholesterol, triglyceride, and LDL cholesterol were significantly higher in adriamycin group compared to the control group. HDL cholesterol was similar in both groups. Total cholesterol and LDL cholesterol level significantly increased over the adriamycin dose. Total fatty acid levels were significantly higher after injection of adriamycin. Long chain fatty acids such as palmitic acid, linoleic acid and oleic acid levels were significantly elevated in the adriamycin group.
Conclusion
: Serum lipid and fatty acid levels increased significantly after injection of adriamycin.

Keywords :Adriamycin, Cardiomyopathy, Lipid, Fatty acid