All issues > Volume 44(2); 2001

Case Report

J Korean Pediatr Soc. 2001;44(2):205-210. Published online February 15, 2001.

A Neonatal Case of Symptomatic Congenital Cytomegalovirus Infection with Hearing Defect

Sung Jun SJ Jang¹, Yoon Jung YJ Cho¹, Sang Lak SL Lee¹, Joon Sik JS Kim¹, Tae Chan TC Kwon¹

¹Department of Pediatrics, School of Medicine, Keimyung University, Taegu, Korea

Abstract

Cytomegalovirus(CMV) is one of the leading cause of intrauterine infections of man with an incidence ranging from 0.48% to 2.2% of all live births. Although the majority of CMV-infected newborns are clinically asymptomatic at birth, some will have signs of congenital infection : Intrauterine growth retardation, petechial or purpuric rash, microcephaly, anemia, thrombocytopenia, jaundice, hepatosplenomegaly and intracranial calcification. We experienced a case of symptomatic congenital CMV infection in a 1-day-old male who presented generalized petechiae, hepatosplenomegaly, anemia, thrombocytopenia. Urine PCR and viral culture for CMV were positive, and a brain CT revealed ventriculomegaly and periventricular calcification. And auditory evoked potential revealed left sensorineural hearing loss. He received ganciclovir treatment for 6 weeks, was discharged in good health, and continued conunder follow-up at the outpatient department.

Keywords :CMV infection, Hearing loss, Newborn