All issues > Volume 44(8); 2001

Original Article

J Korean Pediatr Soc. 2001;44(8):893-898. Published online August 15, 2001.

Serial Changes of CK, CK-MB after Radiofrequency Catheter Ablation in Pediatric Patients

Se Young SY Kim¹, Myung Chul MC Hyun¹

¹Department of Pediatrics, College of Medicine, Kyungpook National University, Taegu, Korea

Abstract

Purpose
: To investigate the degree of myocardial injury incurred by radiofrequency catheter ablation(RFCA), we serially measured CK, CK-MB levels in 24 pediatric paroxysmal supraventricular tachycardia patients undergoing RFCA(male : 12, female : 12, mean age : 10.5 years, mean weight : 37.2 kg).
Methods
: We serially measured blood CK, CK-MB levels, 1 day before RFCA(baseline), 8 hours after RFCA(stage 1), 16 hours after RFCA(stage 2), 24 hours after RFCA. Serial changes of CK, CK-MB levels were compared with baseline levels, age, body weight, number of applied RFCAs, total duration of RFCAs and the site of ablation(left heart ablation, right heart ablation).
Results
: Compared with baseline levels of CK, CK-MB, there were significant increases in CK and CK-MB levels in stage 1(base line : 130.7±54.0 U/L, 1.97±1.74 μg/L, stage 1 : 233.7±165.1, P=0.04, 7.71±7.96, P=0.01, stage 2 : 207.4±131.3, P=0.19, 6.51±8.54, P=0.08, stage 3 : 215.7±151.4, P=0.13, 5.09±4.38, P=0.36). The CK level was found to be elevated(>195 u/L) in 13 patients(54 %), while the CK-MB level was elevated(>5 μg/L) in 12 patients(50%). Comparing left heart ablations(n=11) and right heart ablations(n=13), CK-MB level in stage 1 was significantly increased in left heart ablation(12.29±9.79 μg/L, 3.82±2.48, P=0.02). In right heart ablations, there were significant correlations between the number of applied RFCAs and CK-MB level in stage 1(P=0.02, r=0.65).
Conclusion
: Significant myocardial injury was incurred by RFCA. Considering the small growing heart of pediatric patients, we should take efforts to minimize myocardial injuries.

Keywords :CK, CK-MB, RFCA, Myocardial injury