All issues > Volume 45(2); 2002

Case Report

J Korean Pediatr Soc. 2002;45(2):256-260. Published online February 15, 2002.

MRI Finding of a Case of Relapsed Acute Mixed Type Leukemia with Bone Marrow Necrosis

Joo Young JY Park¹, Euk E Park¹, Seat Byeoul SB Park¹, Dong Seok DS Jeon², Hee Jung HJ Lee³, Heung Sik HS Kim¹, Chin Moo CM Kang¹

¹Department of Pediatrics, College of Medicine, Keimyung University, Daegu, Korea
²Department of Clinical Pathology, College of Medicine, Keimyung University, Daegu, Korea
³Department of Diagnostic Radiology, College of Medicine, Keimyung University, Daegu, Korea

Correspondence Heung Sik HS Kim ,Email: kimhs@dsmc.or.kr

Abstract

Bone marrow necrosis is a rare complication of a variety of diseases affecting the marrow. The cause and incidence are unknown, and reports of treatment response are rare. We describe a case of relapsed acute mixed type leukemia with bone marrow necrosis. The patient was a 10 year old female diagnosed with acute mixed type leukemia four years ago. She had been on second remission state for 1 year, presented with severe back pain, tenderness in lower extremities, low-grade fever and general weakness. Her level of serum lactic dehydrogenase on admission was increased. Bone marrow aspiration from both posterior iliac crest showed marrow necrosis. Subsequent examination showed the same feature. Hip MRI showed heterogenous low signal intensity in both iliac bone on T-1 weighted image and heterogenous high signal intensity on T-2 wieghted image. Remission induction therapy was started but she expired on 59th hospital day due to the complication of sepsis.

Keywords :Bone marrow necrosis, Leukemia