All issues > Volume 45(4); 2002

Original Article

J Korean Pediatr Soc. 2002;45(4):498-504. Published online April 15, 2002.

The Influence of the Preoperative Chronic Cyanosis on the Cardiac Troponin I in the Pediatric Cardiac Operation

Jinyoung JY Song¹, Sungkyu SK Lee¹, Jaeyoung JY Lee¹, Soojin SJ Kim¹, Wooseup WS Shim¹

¹Department of Pediatric, Sejong General Hospital, Pucheon, Korea

Correspondence Jinyoung JY Song ,Email: amyjys@hanmail.net

Abstract

Purpose
: The purpose of this study was to evaluate the perioperative myocardial damage in pediatric congenital heart disease with the cardiac specific protein of cardiac troponin I(cTpn-I).
Methods
: All 25 pediatric patients who were diagnosed with tetralogy of Fallot or double outlet right ventricle were classified as group A(acyanotic, SaO2 >90%), group B(mildly cyanotic, SaO2 >80-90%) and group C(moderately cyanotic, SaO2 <80%). The control group D was consisted of 10 patients with ventricular septal defects who were operated in the same period. We measured preoperative hemoglobin, preoperative and postoperative(24 and 72 hour) arterial oxygen saturation, cTpn-I and creatine kinase(CK-MB).
Results
: Total 25 patients were subdivided into 6 of group A, 12 of group B and 7 of group C. The concentrations of preoperative cTpn-I were 0.23?.12 ng/mL in group A, 0.25?.12 ng/mL in group B, 0.26?.13 ng/mL in group C. And the concentrations of cTpn-I in postoperative 24 hour were 10.04?.28 ng/mL in group A, 12.50?.86 ng/mL in group B, 12.55?.90 ng/mL in group C. Which revealed cTpn-I in group C was higher than that of the another less cyanotic groups. In addition, the concentration of cTpn-I of group C in postoperative 72 hour was higher than any other groups. The concentration of cTpn-I in postoperative 72 hour was statistically correlated with that in postoperative 24 hour and preoperative arterial oxygen saturation(P=0.001).
Conclusion
: Preoperative chronic cyanosis can influence on the postoperative concentration of cTpn-I in pediatric cardiac patients, which means impairment on the postoperative myocardial recovery.

Keywords :Cyanosis, Cardiac Troponin I, Myocardium, Cardiac operation