All issues > Volume 45(7); 2002

Case Report

J Korean Pediatr Soc. 2002;45(7):912-916. Published online July 15, 2002.

A Successful Transplant of HLA-3 Loci Mismatched Umbilical Cord Blood into a Patient with Acute Myeloid Leukemia from an Unrelated Donor

Byoung Chul BC Kwon¹, Kyung Mi KM Shin¹, Sung Chul SC Won¹, Chuhl Joo CJ Lyu¹, Chang Hyun CH Yang¹, Hyun Ok HO Kim²

¹Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
²Department of Clinical Pathology, College of Medicine, Yonsei University, Seoul, Korea

Correspondence Chuhl Joo CJ Lyu ,Email: cj@yumc.yonsei.ac.kr

Abstract

Cord blood is a useful source of allogeneic hematopoietic stem cells for bone marrow reconstitution. The number of umbilical cord blood transplants is increasing worldwide. In this a case 15- month-old boy with acute myeloid leukemia was treated with umbilical cord blood transplant from an HLA-3 loci mismatched unrelated donor. Granulocyte recovery greater than 500/mm3 occurred at day 49, and the platelet recovered greater than 20,000/mm3 independent of transfusion at day 81 after stem cell infusion.

Keywords :Cord blood transplantation, HLA-3 loci mismatching, Unrelated donor