All issues > Volume 45(8); 2002

Case Report

J Korean Pediatr Soc. 2002;45(8):1028-1032. Published online August 15, 2002.

A Case of Subcutaneous Panniculitis-like T Cell Lymphoma in Childhood

Yoon Seok YS Choi¹, Kyung Mi KM Shin¹, Sung Chul SC Won¹, Chuhl Joo CJ Lyu¹, Chang Hyun CH Yang¹, Byung Soo BS Kim¹, Moon Kyu MK Kim²

¹Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
²Department of Pediatrics, College of Medicine, Aju University, Suwon, Korea

Correspondence Chuhl Joo CJ Lyu ,Email: cj@yumc.yonsei.ac.kr

Abstract

Subcutaneous pannicultis-like T cell lymphoma is a rare cutaneous T cell lymphoma. It presents with multiple subcutaneous nodules or plaques involving the extremities or trunk, and with constitutional symptoms that include fever, malaise, fatigue, myalgia, chills and weight loss. Histologically, the lesions of this disease are reminiscent of panniculitis and are composed of a mixture of small and large atypical lymphoid cells infiltrating between adipocytes. The optimal treatment for this disease is undefined and prognosis of this disease is poor, even when treated with multiagent chemotherapy regimens considered optimal for agressive lymphoma of other types. Poor prognosis factors include clinical features such as anemia, leukocytopenia, hepatosplenomegaly, lymphadenopathy and coagulopathy, which are suggestive of hemophagocytosis. Much of the mortality of this disease is due not to disseminated lymphoma with organ failure, but rather to complications of the cytopenias associated with the hemophagocytic syndrome. We report a case of subcutaneous panniculitis-like T cell lymphoma in a 12 year-old boy who presented with initial complaints of fever and multiple subcutaneous nodules, and briefly review the related literature.

Keywords :Subcutaneous panniculitis-like T cell lymphoma