All issues > Volume 45(9); 2002

Case Report

J Korean Pediatr Soc. 2002;45(9):1146-1149. Published online September 15, 2002.

A Case of Stevens-Johnson Syndrome Plus Vanishing Bile Duct Syndrome Associated with Ibuprofen Use

Jee Yee JY Choi¹, Su Young SY Kim¹, Soon Ok SO Byun¹, Jae Hong JH Park²

¹Department of Pediatrics, Wallace Memorial Baptist Hospital, Pusan, Korea
²Department of Pediatrics, College of Medicine, Pusan University, Pusan, Korea

Correspondence Jee Yee JY Choi ,Email: toofar7777@hanmaill.net

Abstract

Acute vanishing bile syndrome is a cause of progressive cholestasis. It is most often drug or toxin related. It's pathogenesis is unknown. Stevens-Johnson syndorme is a well-recognized immune complex-mediated hypersensitivity reaction. It is induced by drug or infection. It has classic systemic, mucosal, and dermatologic manifestations. We report a case of a 14 years old female suffering from Stevens-Johnson syndrome plus vanishing bile duct syndrome associated with ibuprofen use. We report the case with a brief review of its related literature.

Keywords :Vanishing bile duct syndorme, Stevens-Johnson syndrome, Ibuprofen