All issues > Volume 45(12); 2002

Case Report

J Korean Pediatr Soc. 2002;45(12):1591-1595. Published online December 15, 2002.

Familial Adenomatous Polyposis Improved by COX-2 Inhibitor in a Child

Ki Won KW Oh¹, Se Young SY Kim¹, Hwan Suk HS Lee¹, Myung Hoon MH Lee², Byung Ho BH Choe¹

¹Department of Pediatrics, Kyungpook National University, School of Medicine, Daegu, Korea
²Department of Pathology, Kyungpook National University, School of Medicine, Daegu, Korea

Correspondence Byung Ho BH Choe ,Email: bhchoi@knu.ac.kr

Abstract

Familial adenomatous polyposis(FAP) is an autosomal dominant disease characterized by numerous adenomas in the colorectum. Patients with FAP are always at risk of malignant transformation, so that colectomy is unavoidable. NSAID, such as sulindac, and selective COX-2 inhibitor, such as celecoxib, have shown a positive effect on FAP by causing polyp regression in some patients. We report a case of FAP in a 9-year-old female whose polyposis regressed markedly after six months-treatment with celecoxib.

Keywords :Familial adenomatous polyposis, NSAID, COX-2 inhibitor, Celecoxib