All issues > Volume 46(2); 2003

Case Report

J Korean Pediatr Soc. 2003;46(2):203-206. Published online February 15, 2003.

Two Cases of Castlema's Disease in Childern

Eun Ah EA Kim¹, Chong Guk CG Lee¹, Han Sung HS Kim²

¹Department of Pediatrics, College of Medicine, Inje University, Seoul Paik Hospital, Korea
²Department of Pathology, College of Medicine, Inje University, Ilsan Paik Hospital, Korea

Correspondence Chong Guk CG Lee ,Email: chonglee@ilsanpaik.ac.kr

Abstract

Castleman's disease is an atypical lymphoproliferative disorder of unknown origin. It has three histologic variants(hyaline vascular, plasma-cell, and mixed) and two clinical types(localized and multicentric). Some sufferers have constitutionalg symptoms and laboratory abnormalities such as anemia, hypoalbuminemia, hypergammaglobulinemia, and elevated erythrocyte sedimentation rate. The localized form is cured by complete surgical excision whereas the multicentric form is managed by prednisone and other immunosuppressor drugs. The prognosis of the multicentric form is worse than the localized form since malignancies and severe infections may lead to a rapidly fatal outcome. Castleman's disease has been rarely reported at pediatric age in Korea. We experienced two cases of Castleman's disease detected at 3 and 5 years of age. They were presented with painless enlargement of submandibulars and axillary lymph nodes but had no associated symptoms. The lesions were excised and diagnosed as Castleman's disease, and no recurrence was noted during follow-up periods.

Keywords :Castleman's disease