All issues > Volume 46(8); 2003

Original Article

J Korean Pediatr Soc. 2003;46(8):817-820. Published online August 15, 2003.

Alteration of Biochemical Profiles after High-Dose Intravenous Immunoglobulin Administration in Kawasaki Disease

Ji-Won JW Lee¹, Kyung-Yil KY Lee¹

¹Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea

Correspondence Kyung-Yil KY Lee ,Email: leekyungyil@yahoo.com

Abstract

Purpose
: Intravenous immunoglobulin(IVIG) has been used as an immunomodulatory treatment for several immune-mediated diseases. The early effect of high-dose IVIG on biochemical profiles including lipids and proteins was evaluated in patients with Kawasaki disease(KD).
Methods
: Twelve children with KD(nine boys) were treated with IVIG of 2 g/kg over 12 hours. Serial sera were collected from the patients four times : before IVIG treatment and two hours, 24 hours and seven days after IVIG treatment. The samples were frozen at -20℃ before biochemical analysis.
Results
: A significant decrease in albumin concentration was found two hours h and 24 hours after IVIG treatment, but this recovered to the pretreatment level after seven days. Total cholesterol and triglyceride increased slightly after seven day. A significant decrease in HDL-cholesterol and C- reactive protein was seen two hours and 24 hours after IVIG treatment.
Conclusion
: High-dose IVIG affects immediate changes in protein profiles and HDL-cholesterol in KD. Changes in HDL-cholesterol induced by IVIG may be the result of changes in systemic protein metabolism.

Keywords :Intravenous immunoglobulin, Kawasaki disease, Proteins, Lipids, HDL-cholesterol